Colourized microscopy images of cells of the malaria parasite

Comparative 3D ultrastructure of Plasmodium falciparum gametocytes

Felix Evers et al. use high-resolution 3D electron microscopy to examine the ultrastructure of sexual and asexual blood stages of the malaria parasite, shedding light on its unique cell biology.

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  • A rift has occurred within the scientific community between two formerly close-knit fields: condensed matter physics and electronic device engineering. What started as a union to understand the fundamental optical and electrical properties of semiconductors has been split by divergent interests. While the partnership has produced revolutionary changes in the way that information is processed and consumed by an increasingly interconnected society, now the two disciplines rarely speak to one another. As the years have passed, condensed matter physics has become enamored with delicate electronic effects in increasingly complex materials and geometries to the detriment of realistic applications. Meanwhile, device engineering has remained steadfastly focused on room-temperature performance and overall efficiency, prizing incremental improvement over potential disruptive advances using alternative materials and physics. Recent advances in topological electronic systems—in particular those exploiting Chern insulators—while elegant, prompt a necessary reexamination of the device engineering needs and the associated metrics with the goal of establishing a commonality within the blooming field of topological electronics. The purpose of this Comment is to initiate such a reexamination in the hopes that, with a better understanding of future device needs, perhaps the two areas may reunite to usher in the next electronic revolution via the use of topological phenomena.

    • Matthew J. Gilbert
    CommentOpen Access
  • NASA’s latest space probe Europa Clipper, was launched on October 14, 2024, and will study Jupiter’s moon Europa. Europa is covered by an icy crust and is thought to host a subsurface ocean of liquid water. Europa Clipper’s main mission objectives are to study the moon’s ice crust and its surface features, confirm the presence of a subsurface ocean, and determine its chemical composition. Ultimately, this mission will further our understanding of the potential habitability of icy moons in our solar system, such as Europa. In this Q&A we are talking with three scientists (Dr. Christopher Glein, Dr. Elodie Lesage and Dr. Annie Marinan) involved with Clipper, and what particular research questions they hope to answer during the mission.

    Q&AOpen Access
  • Topology and chirality of fermionic quasiparticles have enabled exciting discoveries, including quantum anomalous Hall liquids and topological superconductivity. Recently, topological and chiral phonons emerge as new and fast-evolving research directions. While these concepts are separately developed, they are intimately connected in the context of Weyl phonons. The couplings between chiral and topological phonons with various electronic and magnetic quasiparticles are predicted to give rise to new quantum states and giant magnetism with fundamental and applicational interests, ranging from quantum information science to dark matter detectors.

    • Tiantian Zhang
    • Shuichi Murakami
    • Hu Miao
    CommentOpen Access
  • Malaria vaccine research has progressed significantly, with RTS,S/AS01 and R21/Matrix-M receiving WHO endorsement in 2021 / 2023. These vaccines show promise, but challenges like vaccine adherence, strain variation, and resistance persist, highlighting the need for more effective, broad-reaching interventions.

    • Jack Feehan
    • Magdalena Plebanski
    • Vasso Apostolopoulos
    CommentOpen Access
  • The natural host for avian influenza virus (AIV) is waterfowl. However, certain subtypes have breached species barriers, causing epizootics in many avian and mammalian species with occasional zoonotic infections in humans. The ongoing spread of highly pathogenic avian influenza (HPAI) A(H5N1) poses a significant and growing public health threat. Here, we discuss recent advances in viral detection and characterization technologies and their integration into the diagnostics and surveillance of AIV within a “One Health” framework.

    • Qian Niu
    • Zhiwen Jiang
    • Shuo Su
    CommentOpen Access
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